Macrophage cell dying in response to TNFR2

using Nanolive Imaging microscope

The Wong lab is a research lab in Zurich, Switzerland. We focus on understanding the patterns and underlying mechanisms behind cell death signaling and disease.

RESEARCH

Our laboratory is interested in identifying how cell death signaling pathways can influence inflammation with the hope of identifying novel targets to turn on or off the immune system.

Determine how cell death signaling is involved in neo-vascularization and the potential role in vascular disease

Delineate how the TNF signaling pathways activate the inflammasome and how monogenic autoinflammatory diseases may influence cytokine storms

PUBLICATIONS

PUBLICATION

RIPK1/RIPK3

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function

TNFR2

Inflammasome activation by TNFR2-specific activation in the absence of XIAP.

TNFR2 initiates a NF-kB gene signature and primes inflammasome components

Loss of XIAP results in TNFR2-induced pyroptosis

cIAP1

Loss of cIAP1 alters permeability to tumor derived lymphotoxin alpha (title)

cIAP1 but not cIAP2 loss in endothelial cells reduces tumor cell extravasation

Primary adult endothelial cells in vessels are not susceptible to TNF induced cell death in the absence of cIAP1 and cIAP2 inhibition.

THE WONG LAB

TEACHING

BLOCK COURSES:

BIO430: Immunology, Fall Semester, 4th Quarter

Description: In this course, you will learn how to use flow cytometry, inhibitors, genetic knock-outs to define forms of cell death.

BIO431: Cell Death, Inflammation and Immunity, Spring Semester, 2nd Quarter

Description: Students join a laboratory, performing experiments for a current research project. In this course, students will be exposed to issues of data reproducibility, interpretation and presentation.

BIO439: Current Topics in Immunology, Fall Semester, 3rd Quarter (odd years)

Description: Students are exposed and study current topics in immunology beyond basic immunology courses, such as tissue resident macrophages, innate lymphoid cells, regulatory T cell subsets and sterile inflammation.

Workshop for Swiss Apoptosis and Autophagy Meeting (formerly Swiss Apoptosis Meeting), held every two years, Fall

SPECIAL LECTURES:

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SEMINARS

Phd COURSES:

BIO668: Cancer Module A, Modes of cell death

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