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Macrophage cell dying in response to TNFR2  

using Nanolive Imaging microscope

The Wong lab is a research lab in Zurich, Switzerland. We focus on understanding the patterns and underlying mechanisms behind cell death signaling and disease.

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RESEARCH

Our laboratory is interested in identifying how cell death signaling pathways can influence inflammation with the hope of identifying novel targets to turn on or off the immune system.

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Determine how cell death signaling is involved in neo-vascularization and the potential role in vascular disease 

Delineate how the TNF signaling pathways activate the inflammasome and how monogenic autoinflammatory diseases may influence cytokine storms

PUBLICATIONS
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PUBLICATION

RIPK1/RIPK3

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function

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PUBLICATION

TNFR2

Inflammasome activation by TNFR2-specific activation in the absence of XIAP. 

 

  • TNFR2 initiates a NF-kB gene signature and primes inflammasome components

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  • Loss of XIAP results in TNFR2-induced pyroptosis

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PUBLICATION

cIAP1

Loss of cIAP1 alters permeability to tumor derived lymphotoxin alpha (title)

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  • cIAP1 but not cIAP2 loss in endothelial cells reduces tumor cell extravasation

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  • Primary adult endothelial cells in vessels are not susceptible to TNF induced cell death in the absence of cIAP1 and cIAP2 inhibition.

TEACHING
  • BME248: Basics in Immunology

 

Description: This course discusses basic immunology including fundamental characteristics of the innate and adaptive immune systems and the cell types involved, discrimination of self and non-self, as well as the interplay of immune cells in health and disease.

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  • BIO431: Cell Death, Inflammation and Immunity, Spring Semester, 2nd Quarter

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Description: Students join a laboratory, performing experiments for a current research project. In this course, students will be exposed to issues of data reproducibility, interpretation and presentation.

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  • IDB401: Brain Biology

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Description: Basic knowledge of the immune system as it pertains to the brain.

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  • BIO668: Cancer Module A, Modes of cell death

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University of Zürich

Department of Molecular Life Sciences

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© 2021 Designed by: IMMERSION CREATIVE

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